Few Things About Pharmaceutical Granulation
Pharmaceutical granulation is a crucial process in the production of pharmaceuticals, where small particles are aggregated into larger granules to improve flowability, compressibility, and dosage uniformity. Here are a few key points about pharmaceutical granulation: Purpose : Granulation helps in the formulation of solid dosage forms such as tablets and capsules. It enhances the flow properties of the powder mixture, reduces dustiness, improves compaction properties, and ensures uniform distribution of active pharmaceutical ingredients (APIs) and excipients. Types of Granulation : Wet Granulation : Involves the addition of a liquid binder to the powder mixture, followed by mixing, wet massing, drying, and sizing. Dry Granulation : Also known as roller compaction, this method involves compacting the powder mixture into flakes or ribbons, followed by milling or screening to obtain granules. Direct Compression : Involves directly compressing the blend of APIs and excipients without pri